Friday, July 31, 2009

Heart Disease- Gut

The gut appears to be the root of many problems, including heart disease. This may be a result of increased bacteria and their toxins crossing the gut and affecting heart function.

Unfortunately...
"In recent research, the gut has received very little attention from cardiologists as its role in the pathogenesis of cardiovascular disease is poorly understood." Eur Heart J 2005 Nov;26(22):2368-74. Epub 2005 Jun 24.

However, we are beginning to understand that when you have a leaky gut, you experience ...

"chronic inflammation and malnutrition....therefore, future studies need to address the pathophysiology of the intestinal barrier whose reactivity seems to be crucial for heart function." Curr Opin Clin Nutr Metabl Care 2008 Sep;11(5):632-9.

While leaky guts may adversely affect heart health, the bacteria that live in the gut also play a role. Microbiota that normally reside in our gut have profound implications on many aspects of human health; the heart is no exception.

"Understanding these microbial activities is central to determining the role of different dietary components in preventing or beneficially impacting on the impaired lipid metabolism and vascular dysfunction that typifies coronary heart disease and type II diabetes."
Curr Med Chem 2006;13(25):3005-21.

An important point to make here is that people who have problems with their gut often have absolutely no gut symptoms! Common extraintestinal manifestations include,

"symptoms of physical distress, such as fibromyalgia and irritable bladder and alterations in vital functions, such as sleep, libido, appetite and energy level." European Journal of Surgery Volume 164, Supplement 583, 31 December 1998 , pp. 29-31(3)

If you have heart disease, be sure to ask your doctor about underlying gut dysfunction that may be making your heart condition even worse.

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