Multiple Sclerosis 2- Gluten

Gluten may have a role in multiple sclerosis... for some people.  In a study of 98 patients with confirmed MS, researchers "found a highly significant increase in titers of immunoglobulin G antibodies against gliadin and tissue transglutaminase in the multiple sclerosis patients."  

They concluded that while "the specific role of these antibodies in the pathogenesis of multiple sclerosis remains uncertain and requires additional research. A gluten free diet should be considered in specific cases of patients who present with gluten antibodies." Ann NY Acad Sci. 2009 Sep;1173:343-9.

Other studies have also suggested a link between MS and gluten although several studies have also refuted any association.  Clearly, we can't make a blanket call for everyone with MS to avoid gluten.  But it is reasonable cause for investigation.  If true, it makes case studies such as this one more understandable. In that paper, the authors suggest that gluten may have triggered, "inflammatory immune-mediated damage of the central nervous system" that presented as MS. Neurol Sci. 2008 Feb;29(1):29-31. Epub 2008 Apr 1.

Gluten is a protein found in wheat, barley & rye (most oats are contaminated with gluten).  At first glance, any association between a grain product and MS may seem absurd.  But when you realize that many individuals have an aberrant immune response against gluten (for reasons not entirely understood), then some similarity with MS becomes a bit more apparent.  In celiac disease, the immune system attacks gluten and often attacks components of our gut.  In MS, the immune system attacks the structures of the central nervous system.  Same army- inappropriate attack in both circumstances- different location.

In fact, there is even a relationship in the genetics behind these two seemingly separate diseases. 

Again, we should avoid making blanket statements about any complex chronic disease.  But it seems appropriate to rule out any involvement of gluten.